The project focused on developing a gemmotherapy extract of rye enriched with the flavonoid chrysin and cyclodextrins, with antioxidant and antifibrotic potential.

 

Stage I: Development of the Gemmotherapy Extract and Assessment of Its Antioxidant Activity

In the first stage, we obtained a gemmotherapy extract from rye rootlets, enriched with nanocomplexes of chrysin and cyclodextrins. This extract was analyzed, revealing a higher flavonoid content, substances beneficial to health. Tests indicated that the enriched extract exhibited stronger antioxidant capacity compared to the simple extract. Based on these results, the extract was selected for further animal testing.

 

Stages II and III: Antifibrotic Evaluation

In the following stages, the extract was tested on mice with hepatic fibrosis, a severe liver condition preceding cirrhosis. Treatment with the enriched rye extract helped reduce hepatic fibrosis, normalizing blood parameters and decreasing collagen accumulation. Detailed analyses showed that the extract significantly improved liver structure, reducing or even reversing the fibrosis process.

 

These results suggest that the gemmotherapy rye extract enriched with chrysin and cyclodextrins could have beneficial effects on liver health, protecting it against pathological alterations.